ABSTRACT
Baclofen is a commonly prescribed muscle relaxant, also used for hiccups and muscle spasm. It is usually administered orally or delivered intrathecal. Baclofen is extensively eliminated through kidneys as unchanged drug, hence renal compromised patients are more prone to risk of accumulation and toxicity. Neurological manifestations are highly prevalent in such patients. Here we delineate a case report on baclofen induced encephalopathy in end stage renal disease (ESRD) patient, which was resolved with the help of prompt hemodialysis.