ACE2 Up-Regulated Expression and DNA Methylation in Gastric Diseases Associated with Helicobacter Pylori Infection: Implications for COVID-19

ABSTRACT

OBJECTIVE: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has broken out globally. As the SARS-CoV-2 receptor, ACE2 determines whether the virus can successfully infect the human body. Helicobacter pylori (H. pylori) infection is also a global health problem. We propose that H. pylori infection may up-regulate the expression of ACE2.

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