Brain Washing System-The System by Which the Wasting Molecules are Removed from Brain

Authors; Mauro Luisetto^*, ¹Muhammad Akram, ¹Areeba Imtiaz, Behzad Nili-Ahmadabadi²

Affiliations:

IMA Academy Natural Science Branch Italy

Department of Eastern Medicine, Government College University Faisalabad-Pakistan

Pharm D, Nano drug delivery (a partnership product Development firm) Chapel Hill NC, USA, behznili@nanodd.com,+1 (919) 617-6266 (NANO)

Citation: Mauro luisetto (2019) Brain Washing System-The System by Which the Wasting Molecule are Removed from Brain. J Anat Pathol, 1(1);1-5.

Copyright: © 2019, Mauro luisetto. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

ABSTRACT:

The Central Nervous System (CNS) is the only organ system of the body which lacks its own waste clearance or lymphatic system, a system which helps in removal of metabolic byproducts and waste solutes. Although the brain plays its role in 25% metabolism of body and comprises only 2% of the total body mass, this high metabolic load needs a proficient system for the removal of waste solutes and for maintaining homeostasis of brain environment. Well-depicted components of waste removalcomprise of perivascular fluid flow and phagocytic immune cell functions, nonetheless, the requirement for dynamic clearance of waste from the brain is getting progressively valued. Latest improvements in lymphatic vascular biologyconfrontthe recommendation that the braindeficitslymphatic removal system or anequivalent. In this review article, a recently discovered waste removal system, the glymphatic system and its functioning is discussed, keeping in view the experimental studies performed on rodents. The glymphatic system is perivascular network dependent of glial cells that serves as a pseudo-lymphatic system in the brain. In the pathway of glymphatic system, cerebrospinal fluid gains entry into brain by means of peri-arterial spaces, moves into the interstitial spaces through perivascular astrocytes and aquaporin-4 channels, and afterwards pushes the peri-venous waste of interstitial fluid (ISF) and its solutes into lymphatic vessels which eventually moves into systemic circulation. Thissystem plays significant role individually and also in combination with authentic lymphatic systemin drainage and getting clearance of wastes from the brain.

KEYWORDS: Brain Washing System, Wasting Molecule, Neurodegenerative Disease, New Strategies, Toxicology

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