Impact of Plasmodium Falciparum Malaria on Liver and Red Blood Cell

ABSTRACT

Malaria remains one of the greatest public health challenges worldwide, particularly in tropical and sub-tropical countries. Estimates about 212 million and 429.000 death per year worldwide. The liver and red blood cell (RBC) are the organ that has clearly changed in the early stages of infection. The aim of this study was to elucidate the inflamed sinusoidal area showing the change of liver morphology in severe Plasmodium falciparum (P. falciparum) malaria infection and red blood cell anatomical changes. P. falciparum malaria invasion associated with endothelial activation and expression of adhesion molecules. Some infected RBCs can be eliminated by the host immune system. However, some carry on infection which leading to severe malaria. Decrease deformability of erythrocyte infected by malaria parasites may play a role of enrichment in the liver. The different sizes and shapes of infected RBC in the liver were resulted diversity morphological of RBCs and their function in the infected organs.

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