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Authors: Mojtaba Mafi, Fateme Rezvani
Affiliation: Medical Doctor/Physician, Tehran University of Medical Science, Tehran, Iran
Bioinformatics, Study Manager
ABSTRACT
Non-Alcoholic Fatty Liver
Disease (NAFLD), is one of the most prevalent liver diseases worldwide which is
raised up increasingly in incidence and
prevalence [1]. It is defined by liver accumulation of triglycerides and free
fatty acids [2]. Metabolic risk factors associated with NAFLD are obesity, Type 2 Diabetes Mellitus (T2DM)
and dyslipidemia [3]. NAFLD patients may develop progressive fibrosis which
yields eventually to progressive steatosis with associated hepatitis, fibrosis,
cirrhosis, and in some cases Hepatocellular Carcinoma (HCC) (4). Clinical
outcomes are consonant with fibrosis stage and is the strongest predictor for
overall and liver-related mortality [5]. NAFLD as an asymptomatic disease
imposes burden in the community as well as patientâ™s family. As recent studies
represented perspective for the future with high prevalence of obesity
correlated with increased risk of NAFLD and also cardiovascular events [6].
Lifestyle modification, early detection and management of NAFLD can greatly
decrease this burden [7].
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