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Authors: *Nwaogwugwu CJ, Nosiri CI, Atasie OC,
Nwadike C
Department of Biochemistry, Faculty of Biological and Physical
Sciences, Abia State University, PMB 2000, Uturu, Nigeria
Department of Medical Laboratory Sciences, Imo State University,
Owerri
ABSTRACT
Beta vulgaris root
extracts are traditionally used as a folk medicine to treat ailments such as
hypertension, hypoglycemic, inflammatory, and hepertocellular disorder. In this
study the antioxidant potential of root extract of B. vulgaris were
mentored in vitro against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and modulatory
effect on rat brain enzymes. Total phenolic, flavonoid contents, and
antioxidant potential against DPPH of the root extracts at varying
concentrations were evaluated using ethyl acetate. Thus concentration of root
extracts of B. vulgaris root at 100, 200, and 400 mg/kg body
weights were administered orally for (7) days to albino rats followed by
evaluated of oxidative stress markers such as thiobarbituric acid reactive
substances (TBARS), Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione
(GSH) in the animals brain homogenate. The percentage inhibition and IC50 value
of the root extracts were significantly (P < 0.01) dose dependent compared
to ascorbic acid standard. Similarly SOD, CAT, and GSH increased significantly
(P < 0.01) in test animals administered 200 and 400 mg/kg of ethyl acetate
extract of B. vulgaris root. The results obtained here suggest
that B. vulgaris roots extracts suggests a neuroprotective
potential of this plant roots.
Citation: Nwaogwugwu
CJ, (2019), Studies on In Vitro and In Vivo Antioxidant
Evaluation and Total Phenolic, Flavonoidal Content Estimation of Beta
vulgaris root. Sci World J Pharm Sci, 1(1); 1-5
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