Probiotics: Benefits for immunity may depend on sex

Admin on 12 / 12 / 2019 under Medical News

For the first time, a new study shows that "Probiotics and prebiotics can have different effects on the immune system in male, compared [with] female, piglets." The findings have important implications for research on the effects of these supplements, as well as for personalized, probiotics-based treatments.

Probiotics are trending in the world of nutrition these days, and a growing body of evidence is suggesting that the hype may well be justified.

Prebiotics, such as the fiber in fruits and vegetables, and probiotics, such as the microorganisms in yogurt and other fermented foods, may keep the whole body healthy by supporting gastrointestinal health and a good balance of bacteria in our guts.

The linkTrusted Source between probiotics and the immune system has also received considerable attention from the medical research community.

Evidence suggests that probiotics help mediate the host's immune response, which is why some researchers believe that probiotics may help treat immune-related conditions such as allergies or eczema.

But immunity differs considerably by sex; the medical community recognizes sex-based disparities in adults' immune responses to various inflammatory and infectious diseases.

However, researchers know less about immunological sex differences in infants and even less about the effect that dietary supplementation with probiotics may have on the early-life development of the immune system.

So, with this in mind, a team led by Marie Lewis, Ph.D. — a lecturer in gut immunology and microbiology at the University of Reading, in the United Kingdom — set out to investigate the effect of pre- and probiotics in young piglets of different sexes.

Lewis and her team published their findings in the journal Frontiers in Immunology.

Sex differences in immune responses

The team used an outbred piglet model to study the potential early sex differences in the immune system. They looked at the immunity in the piglets' mucosal surfaces, as well as systemic immune responses to new foreign "intruders," or antigens.

The team found that, at just 28 days old, the piglets showed significant sex-based differences. The immune cells, antibodies, and other immune-related molecules were different in males and females in response to probiotic supplementation.

For instance, males and females responded differently to inulin — a prebiotic derived from the chicory plant. Female pigs produced more of the immunoglobulins IgA and IgM in their lymph tissue, while in male pigs, the process occurred in the large intestine.

Also, "The prebiotic inulin significantly increase[d] the number of cells responsible for controlling immune responses, the regulatory T cells, in male guts but not in female guts," reports Lewis.

"This suggests that, during infancy, females may have greater potential for local immune regulation than their male counterparts," write the authors.

Furthermore, they report, "Starch supplementation had no effect on females but increased IgM synthesis in all tissues in males."